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Roundup
Material Safety Data Sheet
Effective
25jan01
MONSANTO Company
Pages: 1-10
ROUNDUP ORIGINAL[TM] Herbicide Version: 1.2 Effective date: 01/25/2001
MONSANTO Company
Material Safety Data Sheet
Commercial Product |
1. PRODUCT AND COMPANY IDENTIFICATION
Product name
ROUNDUP ORIGINAL[TM] Herbicide
EPA Reg. No.
524-445
Product use
Herbicide
Chemical name
Not applicable
Synonyms
None
Company
MONSANTO Company, 800 N. Lindbergh Blvd., St. Louis, MO,
63167
Telephone: 800-332-3111, Fax: 314-694-5557
Emergency numbers
FOR CHEMICAL EMERGENCY, SPILL LEAK, FIRE, EXPOSURE, OR ACCIDENT
Call CHEMTREC- Day or Night 1-800-424-9300 toll free in the continental
U.S., Puerto Rico, Canada, or Virgin Islands. For calls originating
elsewhere: 703-527-3887 (collect calls accepted).
FOR MEDICAL EMERGENCY - Day or Night: 314-694-4000 (collect
calls accepted).
2. COMPOSITION/INFORMATION ON INGREDIENTS
Active ingredient
Isopropylamine salt of N-(phosphonomethyl)glycine: (Isopropylamine
salt of glyphosate
Composition
COMPONENT CAS No. % by weight (approximate)
Isopropylamine salt of glyphosate 38641-94-0 41
Surfactant 61791-26-2 8
Water 7732-18-5 51
Trade secret composition.
OSHA Status
This product is hazardous according to the OSHA Hazard
Communication Standard, 29 CFR 1910.1200.
3. HAZARDS IDENTIFICATION
Emergency overview
Appearance and odour (colour/form/odour): / Liquid / Slight
WARNING!
Keep out of reach of children.
CAUSES SUBSTANTIAL BUT TEMPORARY EYE INJURY
HARMFUL IF SWALLOWED
HARMFUL IF INHALED
REFORMULATION IS PROHIBITED
SEE INDIVIDUAL CONTAINER LABEL FOR REPACKAGING LIMITATIONS
Potential health effects
Likely routes of exposure
Skin contact, eye contact
Eye contact short term
Causes temporary eye irritation.
Skin contact short term
Not expected to produce significant adverse effects when recommended
use instructions are followed.
Inhalation, short term
Not expected to produce significant adverse effects when recommended
use instructions are followed.
Refer to section 11 for toxicological and section
12 for environmental information
4. FIRST AID MEASURES
Eve contact
Immediately flush with plenty of water.
Continue for at least 15 minutes.
If easy to do, remove contact lenses.
If there are persistent symptoms, obtain medical advice.
Skin contact
Wash affected skin with plenty of water.
Wash clothes before re-use.
Take off contaminated clothing, wristwatch, jewellery.
Inhalation
Remove to fresh air.
Ingestion
Immediately offer water to drink.
Do NOT induce vomiting unless directed by medical personnel.
If symptoms occur, get medical attention.
Advice to doctors
This product is not an inhibitor of
cholinesterase.
Antidote
Treatment with atropine and oximes is not
indicated.
5. FIRE FIGHTING MEASURES
Flash point
Does not flash.
Extinguishing media
Recommended: Water, dry chemical, carbon dioxide
(C02), foam
Unusual fire and explosion hazards
None.
Environmental precautions: see section 6.
Hazardous products of combustion
Carbon monoxide (CO), nitrogen oxides (NOx),
phosphorus oxides (PxOy)
Fire fighting equipment
Self-contained breathing apparatus.
Equipment should be thoroughly decontaminated after use.
6. ACCIDENTAL RELEASE MEASURES
Personal precautions
Use personal protection recommended in section 8.
Environmental precautions
SMALL QUANTITIES:
Low environmental hazard.
LARGE QUANTITIES:
Minimize spread.
Keep out of drains, sewers, ditches and water ways.
Methods for cleaning up
SMALL QUANTITIES:
Flush spill area with water.
LARGE QUANTITIES:
Absorb in earth, sand or absorbent material.
Dig up heavily contaminated soil.
Collect in containers for disposal.
Refer to section 7 for types of containers.
Flush residues with small quantities of water.
Minimize use of water to prevent environmental contamination.
Refer to section 13 for disposal of spilled
material.
7. HANDLING AND STORAGE
Handling
Good industrial practice in housekeeping and
personal hygiene should be followed.
Avoid contact with skin and eyes.
When using do not eat, drink or smoke.
Wash hands thoroughly after handling or contact.
Thoroughly clean equipment after use.
Emptied containers retain vapour and product residue.
Observe all labelled safeguards until container is cleaned, reconditioned
or destroyed.
Emptied containers retain vapour and product residue.
FOLLOW LABELED WARNINGS EVEN AFTER CONTAINER IS EMPTIED.
Storage
Compatible materials for storage: stainless
steel, aluminium, plastic, fiberglass, glass lining
Incompatible materials for storage: galvanized steel, unlined mild steel,
see section 10.
Keep out of reach of children.
Keep away from food, drink and animal feed.
Keep only in the original container.
Partial crystallization may occur on prolonged storage below the minimum
storage temperature.
If frozen, place in warm room and shake frequently to put back into
solution.
Minimum shelf life: 5 years.
8. EXPOSURE CONTROLS/PERSONAL PROTECTION
Airborne Exposure Limits
Components Exposure Guidelines
Isopropylamine salt of glyphosate No specific occupational exposure limit has been established.
Surfactant No specific occupational exposure limit has been established.
Water No specific occupational exposure limit has been established.
Engineering controls
Have eye wash facilities immediately available at
locations where eye contact can occur.
Eye protection
If there is potential for contact:
Wear chemical goggles.
Skin protection
If repeated or prolonged contact:
Wear chemical resistant gloves.
Respiratory protection
No special requirement when used as recommended.
When recommended, consult manufacturer of personal
protective equipment for the appropriate type of equipment for a given
application.
9. PHYSICAL AND CHEMICAL PROPERTIES
These physical data are typical values based on
material tested but may vary from sample to sample. Typical values should
not be construed as a guaranteed analysis of any specific lot or as
specifications for the product.
Form: Liquid
Odour: Slight
Flash point: Does not flash.
Specific gravity: 1.1655 @ 20°C/15.6°C
pH: 4.4 - 5.0
Partition coefficient (log Pow): < 0.000 (active ingredient)
10. STABILITY AND REACTIVITY
Stability
Stable under normal conditions of handling and
storage.
Hazardous decomposition
Thermal decomposition: No data.
Hazardous products of combustion: see section 5.
Materials to avoid/Reactivity
Reacts with bases to liberate heat.
Reacts with galvanized steel or unlined mild steel to produce hydrogen, a
highly flammable gas that could explode.
Hazardous polymerization
Does not occur.
11. TOXICOLOGICAL INFORMATION
This section is intended for use by toxicologists
and other health professionals. Data obtained on product or on similar
products are summarized below. Data obtained on active ingredient are
summarized below.
Acute oral toxicity
Rat, LD50 (limit test): > 5,000 mg/kg body weight
Other effects: breathing difficulty, decreased activity, soft
stools
Practically non-toxic.
FIFRA category IV.
No mortality.
Acute dermal toxicity
Rat, LD50 (limit test): > 5,000 mg/kg body weight
Target organs/systems : None.
Other effects: None.
Practically non-toxic.
FIFRA category IV.
No mortality.
Acute inhalation toxicity
Rat, LC50, 4 hours, aerosol: 2.6 mg/L
Target organs/systems : None.
Other effects: breathing difficulty, decreased activity, local
effects
Practically non-toxic.
FIFRA category IV.
Skin irritation
Rabbit 6 animals, OECD 404 test
Days to heal: 1
Primary Irritation Index (PII): 0.4/8.0
Other effects: None.
Essentially non irritating.
FIFRA category IV.
Eye irritation
Rabbit 6 animals , OECD 405 test
Days to heal: 10
Moderate irritation.
FIFRA category II.
Skin sensitization
Guinea pig, Buehler test
Positive incidence: 0 %
EXPERIENCE WITH HUMAN EXPOSURE
Ingestion, short term. case report(s):
Gastro-intestinal effects: irritation,
nausea/vomiting, diarrhea
Ingestion, short term:
Respiratory effects: increased fluid in lungs (lung/pulmonary
oedema)
Cardiovascular effects: decreased blood pressure (hypotension)
Similar formulation
Acute oral toxicity
Rat, LD50:
5,000 mg/kg body weight
Slightly toxic. FIFRA category III.
Acute dermal toxicity
Rabbit LD50 (limit test):
> 5,000 mg/kg body weight
Practically non-toxic. FIFRA category IV. No mortality.
Skin irritation
Rabbit 6 animals, OECD 404 test
Days to heal: 3
Primary Irritation Index (PII): 1.0/8.0
Slight irritation.
FIFRA category IV.
Eye irritation
Rabbit 6 animals , OECD 405 test
Days to heal: > 21
Other effects: pannus, tissue destruction in eye (necrosis of
conjunctivae)
Severe irritation. FIFRA category I.
Acute inhalation toxicity
Rat, LC50, 4 hours, aerosol:
3.28 mg/L
Practically non-toxic.
FIFRA category IV.
Skin sensitization
Guinea pig, 9-induction Buehler test
Positive incidence: 0 "/o
EXPERIENCE WITH HUMAN EXPOSURE
Ingestion, excessive, intentional misuse:
Respiratory effects:
pneumonitis (aspiration)
Gastro-intestinal effects: nausea/vomiting, diarrhea,
abdominal pain, bloody vomiting (haematemesis)
Cardiovascular effects: abnormal heart rhythm
(cardiac dysrhythmia), decreased heart output (myocardial depression)
General/systemic effects: disturbances of fluid and
electrolyte regulation, abnormally decreased blood volume (hypovolaemia),
elevated serum amylase, fluid loss (haemoconcentration), no cholinesterase
inhibition
Laboratory effects -blood chemistry: elevated serum
transaminases, mild acidosis
Eve contact short term. epidemiological:
Note: No cases of irreversible eye effects could be
attributed to glyphosate formulations in an extensive epidemiological
survey of reported accidental eye contact with these formulations.
N-(phosphonomethyl)glycine
Mutagenicity
In vitro and in vivo mutagenicity test(s):
Not mutagenic.
Repeated dose toxicity
Rabbit dermal, 21 days:
NOAEL toxicity: > 5,000 mg/kg body weight/day
Target organs/systems : None.
Other effects: None.
Rat, oral, 3 months: NOAEL toxicity: > 20,000 mg/kg diet
Target organs/systems : None.
Other effects: None.
Carcinogenicity
Mouse, oral, 24 months:
NOEL tumour. > 30,000 mg/kg diet
NOAEL toxicity: - 5,000 mg/kg diet
Tumours: None.
Target organs/systems : liver
Other effects: decrease of body weight gain, histopathologic
effects
Rat, oral, 24 months:
NOEL tumour. > 20,000 mg/kg
diet
NOAEL toxicity: - 8,000 mg/kg diet
Tumours: None.
Target organs/systems: eyes
Other effects: decrease of body weight gain, histopathologic
effects
Toxicity to reproduction/fertility
Rat, oral, 3 generations:
NOAEL toxicity: > 30 mg/kg body weight
NOAEL reproduction: > 30 mg/kg body weight
Target organs/systems in parents: None.
Other effects in parents: None.
Target organs/systems in pups: None.
Other effects in pups: None.
Developmental toxicity/teratogenicity
Rat, oral, 6 - 19 days of gestation:
NOAEL toxicity: 1,000 mg/kg body weight
NOAEL development: 1,000 mg/kg body weight
Other effects in mother animal: decrease of body weight gain,
decrease of survival
Developmental effects: weight loss, post-implantation loss,
delayed ossification
Effects on offspring only observed with maternal toxicity.
Rabbit oral, 6 - 27 days of gestation:
NOAEL toxicity: 175 mg/kg body weight
NOAEL development: 175 mg/kg body weight
Target organs/systems in mother animal: None.
Other effects in mother animal: decrease of survival
Developmental effects: None.
12. ECOLOGICAL INFORMATION
This section is intended for use by
ecotoxicologists and other environmental specialists.
Monsanto has not conducted environmental studies on
this product. Data obtained on similar products are summarized below.
Similar formulation
Aquatic toxicity, fish
Bluegill sunfish (Lepomis macrochirus):
Acute toxicity, 96 hours, flowthrough, LC50: 5.8 mg/L
moderately toxic
Rainbow trout (Oncorhynchus mykiss):
Acute toxicity, 96 hours, flowthrough, LC50: 8.2 mg/L
moderately toxic
Aquatic toxicity, invertebrates
Water flea (Daphnia magna):
Acute toxicity, 48 hours, static, EC50: 12.9 mg/L slightly toxic
Aquatic toxicity, algae/aquatic plants
Green algae (Selenastrum capricornutum):
Acute toxicity, 96 hours, static, EC50: 2.6 mg/L moderately
toxic
Avian toxicity
Bobwhite quail (Colinus virginianus):
Dietary toxicity, 5 days, LC50: > 5,620 mg/kg diet
practically nontoxic
Mallard duck (Anas platyrhynchos):
Dietary toxicity, 5 days, LC50: > 5,620 mg/kg diet
practically non-toxic
Arthropod toxicity
Honey bee (Apis mellifera):
Oral/contact, 48 hours, LD50: > 100 µg/bee
practically non-toxic
Soil organism toxicity, invertebrates
Earthworm (Eisenia foetida):
Acute toxicity, 14 days, LC50: > 5,000 mg/kg dry soil
practically non-toxic
N-(phosphomethyl)glycine: (glyphosate)
Bioaccumulation
Bluegill sunfish (Lepomis macrochirus):
Whole fish: BCF: < 1
No significant bioaccumulation is expected.
Dissipation
Soil, field:
Half life: 2 - 174 days
Koc: 884 - 60,000 L/kg
Binds strongly to soil.
Water, aerobic:
Half life: < 7 days
Identical product without green dye
Biodegradation
Zahn-Wellens test:
Degradation: 80 "/o within 28 days
Inherently biodegradable.
13. DISPOSAL CONSIDERATIONS
Product
Dispose of as hazardous industrial waste.
Recycle if appropriate facilities/equipment available.
Burn in special, controlled high temperature incinerator.
Keep out of drains, sewers, ditches and water ways.
Follow all local/regional/national regulations.
Container
Triple rinse empty containers.
Pour rinse water into spray tank.
Store for collection by approved waste disposal service.
Dispose of as hazardous industrial waste.
Do NOT re-use containers.
Follow all local/regional/national regulations.
14. TRANSPORT INFORMATION
The data provided in this section is for
information only. Please apply the appropriate regulations to properly
classify your shipment for transportation.
Not hazardous under the applicable DOT, ICAO/IATA,
IMO, TDG and Mexican regulations.
15. REGULATORY INFORMATION
TSCA Inventory
All components are on the US EPA's TSCA Inventory
SARA Title III Rules
Section 311/312 Hazard Categories
Immediate
Section 302 Extremely Hazardous Substances
Not applicable.
Section 313 Toxic Chemical(s)
Not applicable.
CERCLA Reportable quantity
Not applicable.
16. OTHER INFORMATION
The information given here is not necessarily
exhaustive but is representative of relevant, reliable data. For more
information refer to product label. Please consult Monsanto if further
information is needed. Follow all local/regional/national regulations. In
this document the British spelling was applied. All trademarks herein are
trademarks of Monsanto Company or its subsidiaries.
Full denomination of most frequently used acronyms.
BCF (Bioconcentration Factor), BOD (Biochemical Oxygen Demand), COD
(Chemical Oxygen Demand), EC50 (50°/ effect
concentration), ED50 (50°/ effect dose), I.M. (intramuscular), I.P. (intraperitoneal),
TV. (intravenous), Koc (Soil adsorption coefficient), LC50 (50°/ lethality
concentration), LD50 (50°/ lethality dose), LDLo (Lower limit of lethal
dosage), LEE (Lower Explosion Limit), LOAEC (Lowest Observed Adverse Effect
Concentration), LOAEL (Lowest Observed Adverse Effect Level), LOEC (Lowest
Observed Effect Concentration), LOLL (Lowest Observed Effect Level), MEL
(Maximum Exposure limit), MTD (Maximum Tolerated Dose), NOAEC (No Observed
Adverse Effect Concentration), NOAEL (No Observed Adverse Effect Level),
NOEC (No Observed Effect Concentration), NOEL (No Observed Effect Level),
OEL (Occupational Exposure Limit), PEL (Permissible Exposure Limit), PII
(Primary Irritation Index), Pow (Partition coefficient n-octanol/water),
S.C. (subcutaneous), STEL (Shot-Term Exposure Limit), TLV-C (Threshold Limit
Value-Ceiling), TLV-TWA (Threshold Limit Value -
Time Weighted Average), UEL (Upper Explosion Limit)
| This Material Safety Data Sheet
(MSDS) serves different purposes than and DOES NOT REPLACE OR MODIFY
THE EPA-APPROVED PRODUCT LABELING (attached to and accompanying the
product container). This MSDS provides important health, safety, and
environmental information for employers, employees, emergency
responders and others handling large quantities of the product in
activities generally other than product use,
while the labeling provides that information specifically for product
use in the ordinary course. Use, storage and disposal of pesticide
products are regulated by the EPA under the authority of the Federal
Insecticide, Fungicide, and Rodenticide Act (FIFRA) through the
product labeling, and all necessary and appropriate precautionary,
use, storage, and disposal information is set forth on that labeling.
It is a violation of federal law to use a pesticide product in an
manner not prescribed on the EPA-approved label.
Although the information and recommendations
set forth herein (hereinafter "Information") are presented in good
faith and believed to be correct as of the date hereof, MONSANTO
Company makes no representations as to the completeness or
accuracy thereof. Information is supplied upon the condition that the
persons receiving same will make their own determination as to its
suitability for the purposes prior to use. In no event will
MONSANTO Company be responsible for damages of any nature
whatsoever resulting from the use of or reliance upon information.
NO REPRESENTATIONS OR WARRANTIES, EITHER EXPRESS OR IMPLIED, OF
MERCHANTABILITY, FITNESS FOR A PARTICULAR PURPOSE OR OF ANY OTHER
NATURE ARE MADE HEREUNDER WITH RESPECT TO INFORMATION OR TO THE
PRODUCT TO WHICH INFORMATION REFERS. |
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